AsurDx™ Clostridium Perfringens Alpha Toxin Antibody Test
The AsurDxTM Clostridium Perfringens Alpha Toxin Antibody Test Kit (Cattle/Goat/Sheep/Pig) is designed for the detection of antibodies to Clostridium Perfringens Alpha Toxin in cattle, goat, sheep and pig serum and plasma samples.
- Detects C. Perfringens Alpha Toxin antibodies of the IgG in serum/plasma of cattle, sheep, goat and pig samples;
- Procedures last less than 75 minutes;
- Provides a simple, rapid, sensitive and cost-effective enzyme-based immunoassay (ELISA) screening method
*Availability/Distribution: Product is designed and developed by BioStone US Texas headquarter and manufactured/assembled by BioStone oversea subsidiaries or partners. Currently, the product is only available outside of the USA. Regulatory requirements vary by oversea countries; the product may not be available in your geographic area.
|Coated Antigen||Alpha Toxin antigen-coated Plate|
|Incubation Time||75 minutes|
|Storage||At least 12 months|
|Specificity||C. Perfringens Alpha Toxin serogroup-specific cattle, sheep, goat or pig antibodies|
|Plates||2 plates||5 plates|
|Plate Format||12 X 8-well strips||12 X 8-well strips|
Enterotoxaemia is a fatal enteric disease that affects all species of domestic animals and is attributable to a toxigenic type of C. perfringens. Most animal diseases due to C. perfringens are intestinal and involve types B, C or D. Type A has been implicated in rare outbreaks of gastritis and hemolytic disease of ruminants (enterotoxemic jaundice, the yellows, yellow lamb disease) and in hemorrhagic enteritis in cattle, horses, dogs and infant alpacas.
The gene encoding the C. perfringens alpha-toxin is present in all strains of C. perfringens (including A, B, C, D, E strains) and the purified alpha-toxin has been shown to be a zinc-containing phospholipase C (PLC) enzyme, which is preferentially active towards phosphatidylcholine and sphingomyelin. The alpha-toxin is hemolytic as a result if its ability to hydrolyze cell membrane phospholipids and this activity distinguishes it from many other related zinc-metallophospholipases C. The alpha-toxin is the major virulence determinant in cases of gas gangrene, and the toxin might play a role in several other diseases of animals and man as diverse as necrotic enteritis in chickens and Crohn’s disease in man.