BioStone Animal Health Launches Clostridium Perfringens Alpha Toxin Antibody Test Kit

DALLAS-FORT WORTH, TX — July 3, 2023 — BioStone Animal Health is pleased to announce the launch of the AsurDx^TM Clostridium Perfringens Alpha Toxin Antibody Test Kit (Cattle/Goat/Sheep/Pig) designed for the detection of antibodies to Clostridium Perfringens Alpha Toxin in cattle, goat, sheep and pig serum and plasma samples. Enterotoxaemia is a fatal enteric disease that affects all species of domestic animals and is attributable to a toxigenic type of C. perfringens. Most animal diseases due to C. perfringens are intestinal and involve types B, C or D. Type A has been implicated in rare outbreaks of gastritis and hemolytic disease of ruminants (enterotoxemic jaundice, the yellows, yellow lamb disease) and in hemorrhagic enteritis in cattle, horses, dogs and infant alpacas.

The gene encoding the C. perfringens alpha-toxin is present in all strains of C. perfringens (including A, B, C, D, E strains) and the purified alpha-toxin has been shown to be a zinc-containing phospholipase C (PLC) enzyme, which is preferentially active towards phosphatidylcholine and sphingomyelin. The alpha-toxin is hemolytic as a result if its ability to hydrolyze cell membrane phospholipids and this activity distinguishes it from many other related zinc-metallophospholipases C. The alpha-toxin is the major virulence determinant in cases of gas gangrene, and the toxin might play a role in several other diseases of animals and man as diverse as necrotic enteritis in chickens and Crohn’s disease in man.

The AsurDx^TM Clostridium Perfringens Alpha Toxin Antibody Test Kit (Cattle/Goat/Sheep/Pig) detects C. Perfringens Alpha Toxin antibodies of the IgG in serum/plasma of cattle, sheep, goat and pig samples. The kit can provide a simple, rapid, sensitive, and cost-effective enzyme-based immunoassay (ELISA) screening method.

About BioStone Animal Health — BioStone Animal Health is a Dallas, TX-based biotechnology company that provides innovative solutions for animal health. BioStone Animal Health works together with our worldwide partners to offer a portfolio of animal disease diagnostic products as well as test kits and reagents for vaccine testing that enables performing a rapid evaluation of the efficacies, stability, consistency, and potency of common animal vaccines. BioStone strives to actively promote and participate in global animal health initiatives by making these test kits available to the international community. For more information about BioStone Animal Health, visit www.biostoneah.com